Dr. Patricio Gariglio Vidal

 

Dr. Patricio Gariglio Vidal

Dr. Patricio Gariglio Vidal

Grado
: Doctor en Ciencias 1973
University of California. USA

Nivel SNI: 3

Tel.: (55) 5747-33-37
Fax: (55) 5747-39-31
E-mail:
vidal@cinvestav.mx

 

Descriptores de la investigación:

Cancer. Oncogenes. E6 y E7 de Papilomavirus,Diagnostico molecular.

Temas de investigación Regulación de la transcripción de genes eucariónticos. Estudio de la expresión de oncogenes (myc, ras) y anti-oncogenes (p53, Rb, TGFbeta) celulares. Regulación epigenética de la expresión de genes supresores de tumor (RARbeta, SLC5A8). Participación de papilomavirus humano (HPV) y de sus oncogenes E6/E7 en cáncer cervico-uterino (CaCu). Importancia del 17beta-estradiol y retinoides en cáncer. Sistemas modelo para estudiar el posible efecto protector de RARbeta (ratones KO) en el desarrollo de CaCu. Diagnóstico molecular de cánceres de alta incidencia en México. Expresión de microRNAs como marcadores para el diagnóstico temprano y pronóstico del cáncer cervical. Mecanismos de acción del resveratrol en proliferación y apoptosis en líneas celulares. Reactivación de la proteína p53 mutante por resveratrol. Genómica y proteómica en sistemas modelo (ratones transgénicos) de cáncer. Papel de las oncoproteínas E6 y E7 en las uniones intercelulares y cáncer invasor.
 
Publicaciones Relevantes
                                     

Hernández-Reséndiz I, Gallardo-Pérez JC, López-Macay A, Robledo-Cadena DX, García-Villa E, Gariglio P, Saavedra E, Moreno-Sánchez R, Rodríguez-Enríquez S. (2018) Mutant p53R248Q downregulates oxidative phosphorylation and upregulates glycolysis under normoxia and hypoxia in human cervix cancer cells. J Cell Physiol. doi: 10.1002/jcp.27354. [Epub ahead of print] Review.

 

Hernandez-Valencia J, Garcia-Villa E, Arenas-Hernandez A, Garcia-Mena J, Diaz-Chavez J, Gariglio P. (2018) Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin.

Nutrients. 23;10(9). pii: E1148. doi: 10.3390/nu10091148.

 

Román-Rosales AA, García-Villa E, Herrera LA, Gariglio P, Díaz-Chávez J. (2018)Mutant p53 gain of function induces HER2 over-expression in cancer cells. BMC Cancer. 3;18(1):709. doi: 10.1186/s12885-018-4613-1.

 

Munguía-Moreno JA, Díaz-Chavéz J, García-Villa E, Albino-Sanchez ME, Mendoza-Villanueva D, Ocadiz-Delgado R, Bonilla-Delgado J, Marín-Flores A, Cortés-Malagón EM, Alvarez-Rios E, Hidalgo-Miranda A, Üren A, Çelik H, Lambert PF, Gariglio P. (2018) Early synergistic interactions between the HPV16‑E7 oncoprotein and 17β-oestradiol for repressing the expression of Granzyme B in a cervical cancer model. Int J Oncol. 53(2):579-591. doi: 10.3892/ijo.2018.4432. Epub 2018 Jun 6.

 

Rodríguez-Uribe G, Serafín-Higuera N, Damian-Morales G, Cortés-Malagón EM, García-Hernández V, Verdejo-Torres O, Campos-Blázquez JP, Trejo-Muñoz CR, Contreras RG, Ocadiz-Delgado R, Palacios-Reyes C, Lambert PF, Griep AE, Mancilla-Percino T, Escobar-Herrera J, Álvarez-Ríos E, Ugarte-Briones C, Moreno J, Gariglio P, Bonilla-Delgado J. (2018) HPV16-E6 Oncoprotein Activates TGF-β and Wnt/β-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model. Biomed Res Int. 16;2018:2847873. doi: 10.1155/2018/2847873. eCollection 2018.

 

Ramírez A, Vera E, Gamboa-Domínguez A, Lambert P, Gariglio P, Camacho J. (2018) Calcium-activated potassium channels as potential early markers of human cervical cáncer. Oncol Lett. 15(5):7249-7254. doi: 10.3892/ol.2018.8187. Epub 2018 Mar 7.

 

Ruíz G, Valencia-González HA, León-Galicia I, García-Villa E, García-Carrancá A, Gariglio P.

(2018) Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis. Stem Cells Int. 2493869. doi: 10.1155/2018/2493869. eCollection 2018.

 

Leon-Galicia I, Diaz-Chavez J, Albino-Sanchez ME, Garcia-Villa E, Bermudez-Cruz R, Garcia-Mena J, Herrera LA, García-Carrancá A, Gariglio P. (2018) Resveratrol decreases Rad51 expression and sensitizes cisplatin‑resistant MCF‑7 breast cancer cells. Oncol Rep. 39(6):3025-3033. doi: 10.3892/or.2018.6336. Epub 2018 Mar 27.

 

Cortés-Malagón EM, Palacios-Reyes C, Romero-Cordoba S, Mendoza-Villanueva D, Escobar-Herrera J, Verdejo-Torres O, Contreras RG, Fernádez-Tilapa G, Moreno-Eutimio MA, Moreno J, Hidalgo-Miranda A, Gariglio P, Bonilla-Delgado J. (2017) The PDZ-Binding Motif of HPV16-E6 Oncoprotein Modulates the Keratinization and Stemness Transcriptional Profile In Vivo. Biomed Res Int. 7868645. doi: 10.1155/2017/7868645. Epub 2017 Oct 10.

 

Medina-Aguilar R, Pérez-Plasencia C, Gariglio P, Marchat LA, Flores-Pérez A, López-Camarillo C, García Mena J. (2017) DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells. Data Brief. 11:169-182. doi: 10.1016/j.dib.2017.02.006. eCollection 2017 Apr.

 

Lagunas-Martínez A, García-Villa E, Arellano-Gaytán M, Contreras-Ochoa CO, Dimas-González J, López-Arellano ME, Madrid-Marina V, Gariglio P. (2017) MG132 plus apoptosis antigen-1 (APO-1) antibody cooperate to restore p53 activity inducing autophagy and p53-dependent apoptosis in HPV16 E6-expressing keratinocytes. Apoptosis. 22(1):27-40. doi: 10.1007/s10495-016-1299-1.

 

Ceja-Rangel HA, Sánchez-Suárez P, Castellanos-Juárez E, Peñaroja-Flores R, Arenas-Aranda DJ, Gariglio P, Benítez-Bribiesca L. (2016) Shorter telomeres and high telomerase activity correlate with a highly aggressive phenotype in breast cancer cell lines. Tumour Biol. 37(9):11917-11926. Epub 2016 Apr 12.

 

Mejía-Rangel J, Córdova E, Orozco L, Ventura-Gallegos JL, Mitre-Aguilar I, Escalona-Guzmán A, Vadillo F, Vázquez-Prado J, Gariglio P, Zentella-Dehesa A. (2016) Pro-adhesive phenotype of normal endothelial cells responding to metastatic breast cancer cell conditioned medium is linked to NFκB-mediated transcriptomic regulation. Int J Oncol. 49(5):2173-2185. doi: 10.3892/ijo.2016.3705. Epub 2016 Sep 26.

 

Organista-Nava J, Gómez-Gómez Y, Ocadiz-Delgado R, García-Villa E, Bonilla-Delgado J, Lagunas-Martínez A, Tapia JS, Lambert PF, García-Carrancá A, Gariglio P. (2016) The HPV16 E7 oncoprotein increases the expression of Oct3/4 and stemness-related genes and augments cell self-renewal. Virology. 499:230-242. doi: 10.1016/j.virol.2016.09.020. Epub 2016 Sep 29.

 

Damian-Morales G, Serafín-Higuera N, Moreno-Eutimio MA, Cortés-Malagón EM, Bonilla-Delgado J, Rodríguez-Uribe G, Ocadiz-Delgado R, Lambert PF, Gariglio P. (2016) The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b(+)Gr1(+) Cells in a Transgenic Mouse Model. Biomed Res Int. 8091353. doi: 10.1155/2016/8091353. Epub 2016 Jul 11.

 

Medina-Aguilar R, Pérez-Plasencia C, Marchat LA, Gariglio P, García Mena J, Rodríguez Cuevas S, Ruíz-García E, Astudillo-de la Vega H, Hernández Juárez J, Flores-Pérez A, López-Camarillo C. (2016) Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol. PLoS One. 11(6):e0157866. doi: 10.1371/journal.pone.0157866. eCollection 2016.

 

Gómez-Gómez Y, Organista-Nava J, Ocadiz-Delgado R, García-Villa E, Leyva-Vazquez MA, Illades-Aguiar B, Lambert PF, García-Carrancá A, Gariglio P. (2016) The expression of miR-21 and miR-143 is deregulated by the HPV16 E7 oncoprotein and 17β-estradiol. Int J Oncol. 49(2):549-58. doi: 10.3892/ijo.2016.3575. Epub 2016 Jun 9.

 

Albino-Sanchez ME, Vazquez-Hernandez J, Ocadiz-Delgado R, Serafin-Higuera N, León-Galicia I, Garcia-Villa E, Hernandez-Pando R, Gariglio P. (2016) Decreased RARβ expression induces abundant inflammation and cervical precancerous lesions. Exp Cell Res. 1;346(1):40-52. doi: 10.1016/j.yexcr.2016.05.010. Epub 2016 May 17.

 

Medina-Aguilar R, Marchat LA, Arechaga Ocampo E, Gariglio P, García Mena J, Villegas Sepúlveda N, Martínez Castillo M, López-Camarillo C. (2016) Resveratrol inhibits cell cycle progression by targeting Aurora kinase A and Polo-like kinase 1 in breast cancer cells.

Oncol Rep. 35(6):3696-704. doi: 10.3892/or.2016.4728. Epub 2016 Apr 4.