Dr. Luis Marat Alvarez Salas

Dr. Luis Marat Alvarez Salas

Grado:
Doctor en Ciencias 1990
Depto. de Genética y Biología Molecular
Cinvestav
México

Nivel SNI: 3

Tel: (55) 5747-3800 ext. 5387 y 5388
Fax: (55) 5747-3392
E-mail:
lalvarez@cinvestav.mx

Descriptores de la investigación:
Terapéutica de Ácidos Nucléicos. Desarrollo de software con aplicación a Biología Molecular. Terapia génica de cáncer cervical. Tecnología antisentido. Ribozimas y DNAzimas. Oligonucleótidos antisentido. ARN de interferencia y microARN (miRNA). Aptámeros y aptazimas Nanotecnología. Cáncer cervical y papilomavirus (VPH).

Publicaciones recientes
Arenas-Hernandez M1,2, Gomez-Lopez N3, Garcia-Flores V4, Rangel-Escareño C5, Alvarez-Salas LM4, Martinez-Acuña N4, Vazquez-Perez JA6, Vega-Sanchez R7. (2019) Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term. Genes Immun. Jan;20(1):56-68. doi: 10.1038/s41435-017-0010-z. Epub Jan 24.
 
Garcia-Flores V, Romero R, Miller D, Xu Y, Done B, Veerapaneni C, Leng Y, Arenas-Hernandez M, Khan N, Panaitescu B, Hassan SS, Alvarez-Salas LM, Gomez-Lopez N. (2018) Inflammation-Induced Adverse Pregnancy and Neonatal Outcomes Can Be Improved by the Immunomodulatory Peptide Exendin-4. Front Immunol. Jun 18;9:1291. doi: 10.3389/fimmu. 01291. eCollection PMID: 29967606
 
Valencia-Reséndiz DG, Palomino-Vizcaino G, Tapia-Vieyra JV, Benítez-Hess ML, Leija-Montoya AG, Alvarez-Salas LM. (2018) Inhibition of Human Papillomavirus Type 16 Infection Using and RNA Aptamer. Nucleic Acid Ther. Apr;28(2):97-105. doi: 10.1089/nat.2017.0687. Epub  Feb 13. PMID: 29437522
 
Zamora-Contreras AM, Alvarez-Salas LM. (2018) Let-7 miRNA Precursors Co-express with LIN28B in Cervical Cells. Microrna. 7(1):62-71. doi: 10.2174/2211536607666180115143014. PMID: 29336272
 
Natalia MA, Alejandro GT, Virginia TJ, Alvarez-Salas LM. (2018) MARK1 is a Novel Target for miR-125a-5p: Implications for Cell Migration in Cervical Tumor Cells. Microrna. 7(1):54-61. doi: 10.2174/2211536606666171024160244. PMID: 29076440
 
Palomino-Vizcaino G, Valencia Reséndiz DG, Benítez-Hess ML, Martínez-Acuña N, Tapia-Vieyra JV, Bahena D, Díaz-Sánchez M, García-González OP, Alvarez-Sandoval BA, Alvarez-Salas LM. (2018) Effect of HPV16 L1 virus-like particles on the aggregation of non-functionalized gold nanoparticles. Biosens Bioelectron. Feb 15;100:176-183. doi: 10.1016/j.bios.2017.09.001. Epub 2017 Sep 4. PMID: 28889068
 
González-Torres A, Bañuelos-Villegas EG, Martínez-Acuña N, Sulpice E, Gidrol X, Alvarez-Salas LM. (2018) MYPT1 is targeted by miR-145 inhibiting viability, migration and invasion in 2D and 3D HeLa cultures. Biochem Biophys Res Commun. Dec 9;507(1-4):348-354. doi: 10.1016/j.bbrc. 11.039. Epub Nov 14. PMID: 30446228
 
Toscano-Garibay JD, Arriaga-Alba M, Sánchez-Navarrete J, Mendoza-García M, Flores-Estrada JJ, Moreno-Eutimio MA, Espinosa-Aguirre JJ, González-Ávila M, Ruiz-Pérez NJ. (2017) Antimutagenic and antioxidant activity of the essential oils of Citrus sinensis and Citrus latifolia. Sci Rep. Sep 13;7(1):11479. doi: 10.1038/s41598-017-11818-5. PMID: 28904369
 
Toscano-Garibay JD1, Benítez-Hess ML, Alvarez-Salas LM. (2017) Targeting of the HPV-16 E7 protein by RNA aptamers. Methods Mol Biol. 1249:221-39. doi: 10.1007/978-1-4939-2013-6_17.
 
Leija-Montoya AG1, Benítez-Hess ML, Toscano-Garibay JD, Alvarez-Salas LM. ( 2014) Characterization of an RNA aptamer against HPV-16 L1 virus-like particles. Nucleic Acid Ther. 24(5):344-355.
 
Benítez-Hess ML, Reyes-Gutiérrez P, Alvarez-Salas LM.  (2011) Inhibition of human papillomavirus expression using DNAzymes. Methods Mol Biol. 764:317-335.
 
López JA, Alvarez-Salas LM. (2011) Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation apoptosis, migration and invasion. Biochem Biophys Res Commun. 409(3):513-519.
 
Aquino-Jarquin G1, Rojas-Hernández R, Alvarez-Salas LM. (2010) Design and function of triplex hairpin ribozymes. Methods Mol Biol. 629:323-338. doi: 10.1007/978-1-60761-657-3_21.
 
Aquino-Jarquin G, Toscano-Garibay JD. (2011) RNA aptamer evolution: two decades of Selection. Int J Mol Sci. 12(12):9155-71. doi: 10.3390/ijms12129155. Epub Dec 8. Review. PMID: 22272125
 
Toscano-Garibay JD, Benítez-Hess ML, Alvarez-Salas LM.  (2011) Isolation and characterization of an RNA aptamer for the HPV-16 E7 oncoprotein. Arch Med Res. Feb;42(2):88-96. doi: 10.1016/j.arcmed.2011.02.005. PMID: 21565620
 
Reyes-Gutiérrez P1, Alvarez-Salas LM. (2009) Cleavage of HPV-16 E6/E7 mRNA mediated by modified 10-23 deoxyribozymes. Oligonucleotides. Sep;19(3):233-42. doi: 10.1089/oli.2009.0193.
 
Alvarez-Salas LM. (2008) Amolimogene bepiplasmid, a DNA-based therapeutic encoding the E6 and E7 epitopes from HPV, for cervical and anal dysplasia. Curr Opin Mol Ther. Dec;10(6):622-8. PMID: 19051140

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