Dr. Jaime García Mena

Dr. Jaime García Mena

Dr. Jaime García Mena

Grado: Doctor en Ciencias 1992
Departamento de Genética y Biología Molecular
Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional.
México

Nivel SNI: 2

Tel: (55) 5747-3800 Ext. 5328
E-mail: jgmena@cinvestav.mx

Descriptores de la investigación:

Microbiota, Microbioma, Obesidad, Diabetes tipo 2, Vía entero-mamaria.

Líneas de investigación:

El trabajo que se desarrolla en este laboratorio está relacionado con:

a) Estudio de la vía Tracto-Digestivo-Materno►Leche-Materna►Tracto-digestivo-neonato.
b) La tipificación genética de poblaciones de microorganismos de interés Médico, Biotecnológico y Ambiental.
c) El estudio de la microbiota y su microbioma en relación a la diabetes tipo 2, diabetes gestacional, obesidad y síndrome metabólico en población Mexicana.
d) El estudio de la microbiota y su microbioma en relación con temas biotecnológicos y ambientales.

Publicaciones relevantes: 

Artículos:

1) Jan-Roblero J, Cancino-Díaz JC, García-Mena J, Nirmalkar K, Zárate-Segura P, Ordaz A, Guerrero-Barajas C. (2020) Assessment of the tolerance to Fe, Cu and Zn of a sulfidogenic sludge generated from hydrothermal vents sediments as a basis for its application on metals precipitation. Mol Biol Rep. Aug;47(8):6165-6177. doi: 10.1007/s11033-020-05690-2. Epub 2020 Aug 4.PMID: 32749633.

2) Hinojosa-Velasco A, de Oca PVB, García-Sosa LE, Mendoza-Durán JG, Pérez-Méndez MJ, Dávila-González E, Ramírez-Hernández DG, García-Mena J, Zárate-Segura P, Reyes-Ruiz JM, Bastida-González F. (2020) A case report of newborn infant with severe COVID-19 in Mexico: Detection of SARS-CoV-2 in human breast milk and stool. Int J Infect Dis. Aug 27;100:21-24. doi: 10.1016/j.ijid.2020.08.055. Online ahead of print.PMID: 32860950 

3) Chávez-Carbajal A, Pizano-Zárate ML, Hernández-Quiroz F, Ortiz-Luna GF, Morales-Hernández RM, De Sales-Millán A, Hernández-Trejo M, García-Vite A, Beltrán-Lagunes L, Hoyo-Vadillo C, García-Mena J. (2020) Characterization of the Gut Microbiota of Individuals at Different T2D Stages Reveals a Complex Relationship with the Host. Microorganisms. 2020 Jan 10;8(1):94. doi: 10.3390/microorganisms8010094.

4) Corona-Cervantes K, García-González I, Villalobos-Flores LE, Hernández-Quiroz F, Piña-Escobedo A, Hoyo-Vadillo C, Rangel-Calvillo MN, García-Mena J. (2020) Human milk microbiota associated with early colonization of the neonatal gut in Mexican newborns. PeerJ. May 22;8:e9205. doi: 10.7717/peerj.9205. eCollection 2020.PMID: 32509465

5) Hernández-Quiroz F, Nirmalkar K, Villalobos-Flores LE, Murugesan S, Cruz-Narváez Y, Rico-Arzate E, Hoyo-Vadillo C, Chavez-Carbajal A, Pizano-Zárate ML, García-Mena J. (2020) Influence of moderate beer consumption on human gut microbiota and its impact on fasting glucose and β-cell function. Alcohol. Jun;85:77-94. doi: 10.1016/j.alcohol.2019.05.006. Epub 2019 Jun 12.PMID: 31201859

6) Alejandra Chávez-Carbajal 1Khemlal Nirmalkar 2Ana Pérez-Lizaur 3Fernando Hernández-Quiroz 4Silvia Ramírez-Del-Alto 5Jaime García-Mena 6César Hernández-Guerrero 7  (2019) Gut Microbiota and Predicted Metabolic Pathways in a Sample of Mexican Women Affected by Obesity and Obesity Plus Metabolic Syndrome. Int J Mol Sci Jan 21;20(2):438.  PMID: 30669548 PMCID: PMC6358992 DOI: 10.3390/ijms20020438

7) Maya-Lucas O, Murugesan S, Nirmalkar K, Alcaraz LD, Hoyo-Vadillo C, Pizano-Zárate ML, García-Mena J. (2019) The gut microbiome of Mexican children affected by obesity. Anaerobe. Feb;55:11-23. doi: 10.1016/j.anaerobe.2018.10.009. Epub 2018 Oct 24.PMID: 30366118

8) Salazar-Huerta MA, Ruiz-Ordaz N, Galíndez-Mayer J, García-Mena J, Juárez-Ramírez C. (2019) Simulation and experimental validation of a gradient feeding system for fast assessment of the kinetic behavior of a microbial consortium in a tubular biofilm reactor. Bioprocess Biosyst Eng. Jan;42(1):17-27. doi: 10.1007/s00449-018-2009-x. Epub 2018 Sep 20.PMID: 30238361

9) Cervantes-González E, Guevara-García MA, García-Mena J, Ovando-Medina VM. (2019) Microbial diversity assessment of polychlorinated biphenyl-contaminated soils and the biostimulation and bioaugmentation processes. Environ Monit Assess. Jan 31;191(2):118. doi: 10.1007/s10661-019-7227-4.PMID: 30706145

10) Kamaraj SK, Rivera AE, Murugesan S, García-Mena J, Maya O, Frausto-Reyes C, Tapia-Ramírez J, Espino HS, Caballero-Briones F. (2019) Electricity generation from Nopal biogas effluent using a surface modified clay cup (cantarito) microbial fuel cell. Heliyon.  Apr 29;5(4):e01506. doi: 10.1016/j.heliyon.2019.e01506. eCollection 2019 Apr.PMID: 31183413 Free PMC article.

11) Salazar-Huerta MA, Ruiz-Ordaz N, Galíndez-Mayer J, García-Mena J, Juárez-Ramírez C. (2019) Simulation and experimental validation of a gradient feeding system for fast assessment of the kinetic behavior of a microbial consortium in a tubular biofilm reactor. Bioprocess Biosyst Eng. Jan;42(1):17-27. doi: 10.1007/s00449-018-2009-x. Epub 2018 Sep 20.PMID: 30238361

12) Murugesan S, Nirmalkar K, Hoyo-Vadillo C, García-Espitia M, Ramírez-Sánchez D, García-Mena J. (2018) Gut microbiome production of short-chain fatty acids and obesity in children. Eur J Clin Microbiol Infect Dis. Apr;37(4):621-625. doi: 10.1007/s10096-017-3143-0. Epub 2017 Dec 2.PMID: 29196878 Review.

13) Nirmalkar K, Murugesan S, Pizano-Zárate ML, Villalobos-Flores LE, García-González C, Morales-Hernández RM, Nuñez-Hernández JA, Hernández-Quiroz F, Romero-Figueroa MDS, Hernández-Guerrero C, Hoyo-Vadillo C, García-Mena J. (2018) Gut Microbiota and Endothelial Dysfunction Markers in Obese Mexican Children and Adolescents. Nutrients. Dec 19;10(12):2009. doi: 10.3390/nu10122009.PMID: 30572569 Free PMC article.

14) Hernandez-Valencia J, Garcia-Villa E, Arenas-Hernandez A, Garcia-Mena J, Diaz-Chavez J, Gariglio P. (2018) Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin. Nutrients. Aug 23;10(9):1148. doi: 10.3390/nu10091148.PMID: 30142917 Free PMC article.

15) Leon-Galicia I, Diaz-Chavez J, Albino-Sanchez ME, Garcia-Villa E, Bermudez-Cruz R, Garcia-Mena J, Herrera LA, García-Carrancá A, Gariglio P. (2018) Resveratrol decreases Rad51 expression and sensitizes cisplatin‑resistant MCF‑7 breast cancer cells. Oncol Rep. Jun;39(6):3025-3033. doi: 10.3892/or.2018.6336. Epub 2018 Mar 27.PMID: 29620223

16) García-Mena J., Murugesan S, Reyes-Mata MP, Nirmalkar K, Chavez-Carbajal A, Juárez-Hernández JI, Torres-Gómez RE, Piña-Escobedo A, Maya O, Hoyo-Vadillo C, Ramos-Ramírez EG, Salazar-Montoya JA,  (2018) Profiling of bacterial and fungal communities of Mexican cheeses by high throughput DNA sequencing. Food Res Int. 2018 Nov;113:371-381. doi: 10.1016/j.foodres.2018.07.023. Epub 2018 Jul 17.PMID: 30195531

17) García-Mena J, Murugesan S, Pérez-Muñoz AA, García-Espitia M, Maya O, Jacinto-Montiel M, Monsalvo-Ponce G, Piña-Escobedo A, Domínguez-Malfavón L, Gómez-Ramírez M, Cervantes-Gonzáles E, Núñez-Cardona MT (2018) Erratum to: Airborne bacterial diversity from the low atmosphere of Greater Mexico City. Microb Ecol. Apr; 75(3):819. doi: 10.1007/s00248-017-1046-3.PMID: 28779293 No abstract available.

18) Medina-Aguilar R, Pérez-Plasencia C, Gariglio P, Marchat LA, Flores-Pérez A, López-Camarillo C, García Mena J. (2017) DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells. Data Brief. Feb 9;11:169-182. doi: 10.1016/j.dib.2017.02.006. eCollection 2017 Apr.PMID: 28229117 Free PMC article. Medina Aguilar et al., 2016 Jun; 35(6):3696-704. doi: 10.3892/or.2016.4728 (A.R. Medina, P. Gariglio, M.J. García, O.E. Arechaga, S.N. ...Martínez et al., 2016) [3]....

19) Alvarado-Gutiérrez ML, Ruiz-Ordaz N, Galíndez-Mayer J, Santoyo-Tepole F, Curiel-Quesada E, García-Mena J, Ahuatzi-Chacón D. (2017) Kinetics of carbendazim degradation in a horizontal tubular biofilm reactor. Bioprocess Biosyst Eng.  Apr; 40 (4):519-528. doi: 10.1007/s00449-016-1717-3. Epub 2016 Dec 22.PMID: 28005180

20) García-Mena J, Murugesan S, Pérez-Muñoz AA, García-Espitia M, Maya O, Jacinto-Montiel M, Monsalvo-Ponce G, Piña-Escobedo A, Domínguez-Malfavón L, Gómez-Ramírez M, Cervantes-González E, Núñez-Cardona MT. (2016) Airborne Bacterial Diversity from the Low Atmosphere of Greater Mexico City. Microb Ecol. Jul;72(1):70-84. doi: 10.1007/s00248-016-0747-3. Epub 2016 Mar 5.PMID: 26944561

21) Medina-Aguilar R, Pérez-Plasencia C, Marchat LA, Gariglio P, García Mena J, Rodríguez Cuevas S, Ruíz-García E, Astudillo-de la Vega H, Hernández Juárez J, Flores-Pérez A, López-Camarillo C. (2016) Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol. PLoS One. Jun 29;11(6):e0157866. doi: 10.1371/journal.pone.0157866. eCollection 2016.PMID: 27355345 Free PMC article.

22) Ulloa-Martínez M, Burguete-García AI, Murugesan S, Hoyo-Vadillo C, Cruz-Lopez M, García-Mena J. (2016) Expression of candidate genes associated with obesity in peripheral white blood cells of Mexican children. Arch Med Sci. Oct 1;12(5):968-976. doi: 10.5114/aoms.2016.58126. Epub 2016 Apr 7.PMID: 27695486 Free PMC article.

23) Medina-Aguilar R, Marchat LA, Arechaga Ocampo E, Gariglio P, García Mena J, Villegas Sepúlveda N, Martínez Castillo M, López-Camarillo C. (2016) Resveratrol inhibits cell cycle progression by targeting Aurora kinase A and Polo-like kinase 1 in breast cancer cells. Oncol Rep. Jun;35(6):3696-704. doi: 10.3892/or.2016.4728. Epub 2016 Apr 4.PMID: 27109433

24) Murugesan S, Ulloa-Martínez M, Martínez-Rojano H, Galván-Rodríguez FM, Miranda-Brito C, Romano MC, Piña-Escobedo A, Pizano-Zárate ML, Hoyo-Vadillo C, García-Mena J. (2015) Study of the diversity and short-chain fatty acids production by the bacterial community in overweight and obese Mexican children. Eur J Clin Microbiol Infect Dis. Jul;34(7):1337-46. doi: 10.1007/s10096-015-2355-4. Epub 2015 Mar 12.PMID: 25761741

25) Mejía-Benítez MA, Bonnefond A, Yengo L, Huyvaert M, Dechaume A, Peralta-Romero J, Klünder-Klünder M, García Mena J, El-Sayed Moustafa JS, Falchi M, Cruz M, Froguel P. (2015) Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. Diabetologia. 2015 Feb;58(2):290-4. doi: 10.1007/s00125-014-3441-3. Epub 2014 Nov 14.PMID: 25394825

Capítulos en libros:

1) Das, A., Pal, M., Garcia-Mena, J., Whalen, W., Woslka, K., Crossley, R., Rees, W.A., vonHippel, P.H., Costantino, N., Court, D.L., Mazzula, M., Altieri, A.S., Byrd, R.A., Chattopadhyay, S., DeVito, J., Ghosh, B. (1996). Components of Multiprotein-RNA Complex that Controls Transcription Elongation in Escherichia coli phage lambda. In Adhya S. L. (Ed). RNA Polymerase and Associated Factors. Methods Enzymol. Vol. 274. Part B. Elsevier Academic Press. San Diego. USA. pp 374-402. ISBN: 0-12-182175-7.
2) Das A., Garcia-Mena J., Jana, N., Lazinski, D., Michaud, G., Sengupta, S., Zhang, Z. (2003). Genetic and biochemical strategies to elucidate the architecture and targets of a processive transcription antiterminator from bacteriophage lambda. In Adhya S.L. & Garges, S. (Eds.) RNA Polymerase and Associated Factors. Methods in Enzymology. Vol. 371. Part D. Elsevier Academic Press. San Diego. USA. pp 438-459. ISBN 0-12-182274-5.
3) Domínguez-Malfavón L., Cervantes-González E., García-Romero J.R., Torres-Mota A.M., Rojas-Avelizapa, N.G. and García-Mena J. Study of the Microbial Diversity of Outdoor Bioaerosols of Mexico City. In: Wang Y., Li S., Huang P., Yang Y., An Y., and Sun X. (Eds), Progress in Environmental Science and Technology (VOL. I). Proceedings of the 2007 International Symposium on Environmental Science and Technology. Beijing, China, November 13-16, 2007. ISBN 978-7-03-020403-5. Published by Science Press 16 Donghuangchenggen North Street, Beijing, 100717, P. R. China.
4) Cervantes-González E., Rojas-Avelizapa L.I., Cruz-Camarillo R., Rojas-Avelizapa, N.G. and García-Mena, J. Isolation and Identification by 16S rDNA Partial Sequencing of Hydrocarbon-Chitinolytic Bacteria Involved in Hydrocarbon Removal Process. In: Wang Y., Li S., Huang P., Yang Y., An Y., and Sun X. (Eds), Progress in Environmental Science and Technology (VOL. I). Proceedings of the 2007 International Symposium on Environmental Science and Technology. Beijing, China, November 13-16, 2007. ISBN 978-7-03-020403-5. Published by Science Press 16 Donghuangchenggen North Street, Beijing, 100717, P. R. China.
5) Kameyama, L., Fernández, L., Bermudez-Cruz, R.M., García-Mena, J., Ishida, C., and Guarneros, G. Properties of a new coliphage group from human intestinal flora. In Pandalai, S.G. (Ed.). Recent Research Developments in Virology. Vol. 3 Part I. TransWorld Research Network (India), 2001. pp 297-303. ISBN: 81-86846-99-9.
6) Camacho-Pérez, B.; Ríos-Leal, E.; Rinderknecht-Seijas, N., García-Mena, J., Poggi-Varaldo H.M. Capítulo 8. Biorremediación de suelos pesados contaminados y producción simultánea de metano con reactores de suelos activados metanogénicas y secuenciales. En: Ríos-Leal, E.; Solorza-Feria, O.; Poggi-Varaldo, H.M. (Eds). Parte 2: Energías Renovables Biológicas y Biohidrógeno. Energías Renovables Biológicas–Hidrógeno–Pilas de combustible–II. Ed. Cinvestav (México), 2010. pp 119-133. México. ISBN: 978-607-00-3608-8.
7) Cruz-Pauseno G., Núñez-Cardona M.T., Díaz-Godoy R. V. y García Mena J. Técnicas Para El Estudio De Bacterias Del Aire En México. En: Sánchez, M. E., Vázquez G. V., Martínez García A., Solano Sosa C. E. y Gutiérrez Chavez E. (Eds). Avance De La Ciencia En México. Capítulo 2, Biología y Química. Centro De Investigaciones En Óptica A. C. (México), 2017. pp 1477-1481. ISBN: 978-607-00-95228-8-9.
8) Hernandez-Valencia J., Garcia-Villa E., Arenas-Hernandez A., Garcia-Mena J., Diaz-Chavez J. and Gariglio P. Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin. In Portillo M. P. and Fernández-Quintela A. (Eds). Benefits of Resveratrol Supplementation. MDPI, St. Alban-Anlage 66, 4052 (Basel, Switzerland). pp 10-26. ISBN 978-3-03921-275-0 (Pbk), ISBN 978-3-03921-276-7 (PDF).