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Dr. Javier Hernández Sánchez
Grado: Doctor en Ciencias. (1992) ENCB-IPN
Nivel SNI: 1
Tel: (55) 5747-3800 Ext. 5336
Fax: (55) 5747-3392
Email: javierh@cinvestav.mx
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Descriptores de la investigación:
Síntesis de proteínas. Uso de codones. Niveles de tRNAs. Regulación traduccional. Trichinella spiralis. Antígenos de larva recien nacida
Temas de investigación:
1. Papel de la proteína ribosomal S1 en la traducción de mRNAs de diferente composición nucleotídica.
2. Regulación transcripcional de los genes del canal CATSPER de calcio en células germinales.
3. Caracterización inmunológica y molecular de antígenos de la larva recién nacida de Trichinella spiralis y su papel en la relación hospedero-parásito.
Publicaciones Relevantes
Hernández-Ancheyta L1, Salinas-Tobón MDR2, Cifuentes-Goches JC1, Hernández-Sánchez J3. (2018) Trichinella spiralis muscle larvae excretory-secretory products induce changes in cytoskeletal and myogenic transcription factors in primary myoblast cultures. Int J Parasitol. 48(3-4):275-285. doi: 10.1016/j.ijpara.2017.10.002.
Jiménez-Badillo SE1, Oviedo N2, Hernández-Guzmán C3, González-Mariscal L3, Hernández-Sánchez J4. (2017) Catsper1 promoter is bidirectional and regulates the expression of a novel lncRNA. Sci Rep. 17;7(1):13351. doi: 10.1038/s41598-017-13867-2.
Mata-Rocha M, Hernández-Sánchez J, Guarneros G, de la Chesnaye E, Sánchez-Tusié AA, Treviño CL, Felix R, Oviedo N. (2014) The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression. FEBS Lett . 588(18):3352-3360.
Mata-Rocha M, Alvarado-Cuevas E, Hernández-Sánchez J, Cerecedo D, Felix R, Hernández-Reyes A, Tesoro-Cruz E, Oviedo N. (2013) Molecular cloning and analysis of the Catsper1 gene promoter. Mol Hum Reprod. 19(5):336-347.
Serafin-Higuera N, Hernandez-Sanchez J, Ocadiz-Delgado R, Vazquez-Hernandez J, Albino-Sanchez ME, Hernandez-Pando R, Gariglio P. (2012) Retinoic acid receptor β deficiency reduces splenic dendritic cell population in a conditional mouse line. Immunol Lett. 146(1-2):15-24
Castillo-Méndez MA, Jacinto-Loeza E, Olivares-Trejo JJ, Guarneros-Peña G, Hernández-Sánchez J. (2012) Adenine-containing codons enhance protein synthesis by promoting mRNA binding to ribosomal 30S subunits provided that specific tRNAs are not exhausted. Biochimie. 94(3):662-672.
Cruz-Castañeda A, Hernández-Sánchez J, Olivares-Trejo JJ. (2009) Cloning and identification of a gene coding for a 26-kDa hemoglobin-binding protein from Entamoeba histolytica. Biochimie. 91(3):383-389.
Jacinto-Loeza E, Vivanco-Domínguez S, Guarneros G, Hernández-Sánchez J. (2008) Minigene-like inhibition of protein synthesis mediated by hungry codons near the start codon. Nucleic Acids Res. 36(13):4233-4241.
Hernández-Sánchez J, Bautista-Santos A, Fernández L, Bermúdez-Cruz RM, Uc-Mass A, Martínez-Peñafiel E, Martínez MA, García-Mena J, Guarneros G, Kameyama L. (2008) Analysis of some phenotypic traits of feces-borne temperate lambdoid bacteriophages from different immunity groups: a high incidence of cor+, FhuA-dependent phages. Arch Virol. 153(7):1271-1280.
Hernández-Sánchez J, Liñan RF, Salinas-Tobón Mdel R, Ortega-Pierres G. (2008) Giardia duodenalis: adhesion-deficient clones have reduced ability to establish infection in Mongolian gerbils. Exp Parasitol. 119(3):364-372.
Salinas-Tobon Mdel R, Navarrete-Leon A, Mendez-Loredo BE, Esquivel-Aguirre D, Martínez-Abrajan DM, Hernandez-Sanchez J. (2007) Trichinella spiralis: strong antibody response to a 49 kDa newborn larva antigen in infected rats. Exp Parasitol. 115(2):160-167.
Delgado-Olivares L, Zamora-Romo E, Guarneros G, Hernandez-Sanchez J. (2006) Codon-specific and general inhibition of protein synthesis by the tRNA-sequestering minigenes. Biochimie. 88(7):793-800.
Oviedo de Anda NA, Kameyama L, Galindo JM, Guarneros G, Hernandez-Sanchez J. (2004) Evidence of bar minigene expression and tRNA2Ile sequestration as peptidyl-tRNA2Ile during lambda bacteriophage development. J Bacteriol. 186(16):5533-5537.
Uc-Mass A, Loeza EJ, de la Garza M, Guarneros G, Hernández-Sánchez J, Kameyama L. (2004) An orthologue of the cor gene is involved in the exclusion of temperate lambdoid phages. Evidence that Cor inactivates FhuA receptor functions. Virology. 329(2):425-433.
Olivares-Trejo JJ, Bueno-Martínez JG, Guarneros G, Hernández-Sánchez J. (2003) The pair of arginine codons AGA AGG close to the initiation codon of the lambda int gene inhibits cell growth and protein synthesis by accumulating peptidyl-tRNAArg4. Mol Microbiol. 49(4):1043-1049.
Valadez JG, Hernández-Sánchez J, Magos MA, Ontiveros C, Guarneros G. (2001) Increased bar minigene mRNA stability during cell growth inhibition. Mol Microbiol. 39(2):361-369.
Cruz-Vera LR, Toledo I, Hernández-Sánchez J, Guarneros G. (2000) Molecular basis for the temperature sensitivity of Escherichia coli pth(Ts). J Bacteriol. 182(6):1523-1528.