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  • 21 / 12 / 2014
Cinvestav - Centro de Investigación y de Estudios Avanzados del I.P.N.

Dr. Gabriel Guarneros Peña

Dr. Gabriel Guarneros Pena

Dr. Gabriel Guarneros Peña
Investigador Emérito

Grado: Dr. en Biología Molecular (1972).
Universidad de California, Berkeley, CA.
USA.
Nivel SNI: Emérito

Tel: (55) 5747-3338
Fax: (55) 5747-3392
E-mail:
gguarner@cinvestav.mx

Descriptores de la investigación:
Regulación traduccional en bacterias. Minigenes. peptidil-tRNA hidrolasa (Pth).

Temas de Investigación: 1) Síntesis de proteínas en bacterias, pausas ribosomales durante la traducción y disociación de los péptidos nacientes. 2) Cambio del marco de traducción mediada por señales en el mRNA y disponibilidad de los tRNAs. 3) Control biológico de cepas clínicas de Pseudomonas aeruginosa con virus (bacteriófagos). 4) Genómica, proteómica, bioinformática y evolución de bacteriófagos.

Publicaciones Relevantes

Mata-Rocha M, Hernández-Sánchez J, Guarneros G, de la Chesnaye E, Sánchez-Tusié AA, Treviño CL, Felix R, Oviedo N. (2014) The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression. FEBS Lett. 588(18):3352-3360.


Cabrera R, Rocha J, Flores V, Vázquez-Moreno L, Guarneros G, Olmedo G, Rodríguez-Romero A, de la Torre M. (2014)
Erratum to: Regulation of sporulation initiation by NprR and its signaling peptide NprRB: molecular recognition and conformational changes.

Appl Microbiol Biotechnol. 98(22):9517.

 

Cabrera R, Rocha J, Flores V, Vázquez-Moreno L, Guarneros G, Olmedo G, Rodríguez-Romero A, de la Torre M. (2014) Regulation of sporulation initiation by NprR and its signaling peptide NprRB: molecular recognition and conformational changes.

Appl Microbiol Biotechnol. 98(22):9399-412.

Santamaría RI, Bustos P, Sepúlveda-Robles O, Lozano L, Rodríguez C, Fernández JL, Juárez S, Kameyama L, Guarneros G, Dávila G, González V. (2014) Narrow-host-range bacteriophages that infect Rhizobium etli associate with distinct genomic types. Appl Environ Microbiol. 80(2):446-454.

Sepúlveda-Robles O, Kameyama L, Guarneros G.(2012) High diversity and novel species of Pseudomonas aeruginosa bacteriophages. Appl Environ Microbiol. 78(12):4510-4515.

Martínez-Peñafiel E, Fernández-Ramírez F, Ishida C, Reyes-Cortés R, Sepúlveda-Robles O, Guarneros-Peña G, Bermúdez-Cruz RM, Kameyama L. (2012) Overexpression of Ipe protein from the coliphage mEp021 induces pleiotropic effects involving haemolysis by HlyE-containing vesicles and cell death. Biochimie. 94(6):1262-1273.

Vivanco-Domínguez S, Bueno-Martínez J, León-Avila G, Iwakura N, Kaji A, Kaji H, Guarneros G. (2012) Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons. J Mol Biol. 417(5):425-439.

Rocha J, Flores V, Cabrera R, Soto-Guzmán A, Granados G, Juaristi E, Guarneros G, de la Torre M. (2012) Evolution and some functions of the NprR-NprRB quorum-sensing system in the Bacillus cereus group. Appl Microbiol Biotechnol. 94(4):1069-1078

Castillo-Méndez MA, Jacinto-Loeza E, Olivares-Trejo JJ, Guarneros-Peña G, Hernández-Sánchez J. (2012) Adenine-containing codons enhance protein synthesis by promoting mRNA binding to ribosomal 30S subunits provided that specific tRNAs are not exhausted. Biochimie. 94(3):662-672


Flores V, López-Merino A, Mendoza-Hernandez G, Guarneros G. (2012) Comparative genomic analysis of two brucellaphages of distant origins. Genomics . 99(4):233-240.

Vivanco-Domínguez S, Bueno-Martínez J, León-Avila G, Iwakura N, Kaji A, Kaji H, Guarneros G. (2012) Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons. J Mol Biol. 13;417(5):425-439.

 

Jacinto-Loeza E, Vivanco-Domínguez S, Guarneros G, Hernández-Sánchez J. (2008) Minigene-like inhibition of protein synthesis mediated by hungry codons near the start codon. Nucleic Acids Res . 36(13):4233-4241.

Hernández-Sánchez J, Bautista-Santos A, Fernández L, Bermúdez-Cruz RM, Uc-Mass A, Martínez-Peñafiel E, Martínez MA, García-Mena J, Guarneros G, Kameyama L. (2008) Analysis of some phenotypic traits of feces-borne temperate lambdoid bacteriophages from different immunity groups: a high incidence of cor+, FhuA-dependent phages. Arch Virol. 153(7):1271-1280.

Delgado-Olivares L, Zamora-Romo E, Guarneros G, Hernandez-Sanchez J. (2006) Codon-specific and general inhibition of protein synthesis by the tRNA-sequestering minigenes. Biochimie. 88(7):793-800.


Uc-Mass A, Loeza EJ, de la Garza M, Guarneros G, Hernández-Sánchez J, Kameyama L. (2004)
An orthologue of the cor gene is involved in the exclusion of temperate lambdoid phages. Evidence that Cor inactivates FhuA receptor functions. Virology. 329(2):425-433.


Oviedo de Anda NA, Kameyama L, Galindo JM, Guarneros G, Hernandez-Sanchez J. (2004)
Evidence of bar minigene expression and tRNA2Ile sequestration as peptidyl-tRNA2Ile during lambda bacteriophage development. J Bacteriol. 186(16):5533-5537.

 

Olivares-Trejo JJ, Bueno-Martínez JG, Guarneros G, Hernández-Sánchez J. (2003) The pair of arginine codons AGA AGG close to the initiation codon of the lambda int gene inhibits cell growth and protein synthesis by accumulating peptidyl-tRNAArg4. Mol Microbiol. 49(4):1043-1049.


Lindsley D, Gallant J, Guarneros G. (2003) Ribosome bypassing elicited by tRNA depletion. Mol Microbiol. 48(5): 1267-1274.  

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