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  • 22 / 07 / 2014
Cinvestav - Centro de Investigación y de Estudios Avanzados del I.P.N.

Dr. Gabriel Guarneros Peña

Dr. Gabriel Guarneros Pena

Dr. Gabriel Guarneros Peña
Investigador Emérito

Grado: Dr. en Biología Molecular (1972).
Universidad de California, Berkeley, CA.
USA.
Nivel SNI: Emérito

Tel: (55) 5747-3338
Fax: (55) 5747-3392
E-mail:
gguarner@cinvestav.mx

Descriptores de la investigación:
Regulación traduccional en bacterias. Minigenes. peptidil-tRNA hidrolasa (Pth).

Líneas de investigación:

Regulación de la síntesis de proteínas en bacterias. Pausas de los ribosomas durante la traducción de los mensajeros. Disociación inducida de los péptidos nacientes (peptidiles-tRNAs) y  liberación de los ribosomas. Cambio del marco de traducción mediada por diferentes señales en el mRNA. Identificación y control de Pseudomonas aeruginosa de origen hospitalario por medio de estrategias basadas en el uso de bacteriófagos específicos. Caracterización genómica informática de los fagos específicos de, o profagos en las cepas de Pseudomonas. Genómica de fagos del agente causal de la brucelosis en mamíferos.

Publicaciones Relevantes
Santamaría RI1, Bustos P, Sepúlveda-Robles O, Lozano L, Rodríguez C, Fernández JL, Juárez S, Kameyama L, Guarneros G, Dávila G, González V. (2013)  Narrow-host-range bacteriophages that infect Rhizobium etli associate with distinct genomic types. 2014 Jan;80(2):446-454.

Sepúlveda-Robles O, Kameyama L, Guarneros G. (2012) High diversity and novel species of Pseudomonas aeruginosa bacteriophages. Appl Environ Microbiol. 78(12):4510-4515.

Martínez-Peñafiel E, Fernández-Ramírez F, Ishida C, Reyes-Cortés R, Sepúlveda-Robles O, Guarneros-Peña G, Bermúdez-Cruz RM, Kameyama L. (2012)
Overexpression of Ipe protein from the coliphage mEp021 induces pleiotropic effects involving haemolysis by HlyE-containing vesicles and cell death.Biochimie. 94(6):1262-1273.

. 94(6):1262-1273.Castillo-Méndez MAJacinto-Loeza EOlivares-Trejo JJGuarneros-Peña GHernández-Sánchez J 94(3):662-672.

Flores V, López-Merino A, Mendoza-Hernandez G, Guarneros G. (2012) Comparative genomic analysis of two brucellaphages of distant origins. Genomics. 99(4):233-240.

Vivanco-Domínguez S, Bueno-Martínez J, León-Avila G, Iwakura N, Kaji A, Kaji H, Guarneros G. (2012) Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons. J Mol Biol. 417(5):425-439.

Rocha J, Flores V, Cabrera R, Soto-Guzmán A, Granados G, Juaristi E, Guarneros G, de la Torre M. (2012) Evolution and some functions of the NprR-NprRB quorum-sensing system in the Bacillus cereus group. Appl Microbiol Biotechnol. 94(4):1069-1078

Hernández-Sánchez J, Bautista-Santos A, Fernández L, Bermúdez-Cruz RM, Uc-Mass A, Martínez-Peñafiel E, Martínez MA, García-Mena J, Guarneros G, Kameyama L. (2008) Analysis of some phenotypic traits of feces-borne temperate lambdoid bacteriophages from different immunity groups: a high incidence of cor+, FhuA-dependent phages. Arch Virol. 153(7):1271-1280.

Jacinto-Loeza E, Vivanco-Domínguez S, Guarneros G, Hernández-Sánchez J. (2008) Minigene-like inhibition of protein synthesis mediated by hungry codons near the start codon. 36(13):4233-4241

Delgado-Olivares L, Zamora-Romo E, Guarneros G, Hernandez-Sanchez J. (2006) Codon-specific and general inhibition of protein synthesis by the tRNA-sequestering minigenes. Biochimie. 88(7)793-800.

Vivanco-Dominguez S, Cruz-Vera LR, Guarneros G. (2006) Excess of charged tRNALys maintains low levels of peptidyl-tRNA hydrolase in pth(Ts) mutants at a non-permissive temperature. Nucleic Acids Res. 34(5):1564-1570.

Uc-Mass A, Loeza EJ, de la Garza M, Guarneros G, Hernandez-Sanchez J, Kameyama L. (2004) An orthologue of the cor gene is involved in the exclusion of temperate lambdoid phages. Evidence that Cor inactivates FhuA receptor functions. Virology. 329(2):425-433.

Cruz-Vera LR, Magos-Castro MA, Zamora-Romo E, Guarneros G. (2004). Ribosome stalling and peptidyl-tRNA drop-off during translational delay at AGA codons. Nucleic Acids Res. 32 (15):4462-4468.

Oviedo de Anda NA, Kameyama L, Galindo JM, Guarneros G, Hernandez-Sanchez J. (2004). Evidence of bar minigene expression and tRNA2Ile sequestration as peptidyl-tRNA2Ile during lambda bacteriophage development. J.Bacteriol. 186(16):5533-5537.

Oviedo NA, Salgado H, Collado-Vides J, Guarneros G. (2004). Distribution of minigenes in the bacteriophage lambda chromosome. Gene. 329:115-124.

Olivares-Trejo JJ, Bueno-Martinez JG, Guarneros G, Hernandez-Sanchez J. (2003) The pair of arginine codons AGA AGG close to the initiation codon of the lambda int gene inhibits cell growth and protein synthesis by accumulating peptidyl-tRNAArg4. Mol Microbiol. 49(4): 1043-1049.

Lindsley D, Gallant J, Guarneros G. (2003) Ribosome bypassing elicited by tRNA depletion. Mol Microbiol. 48(5): 1267-1274.

Cruz-Vera LR, Hernandez-Ramon E, Perez-Zamorano B, Guarneros G. (2003) The rate of peptidyl-tRNA dissociation from the ribosome during minigene expression depends on the nature of the last decoding interaction. J Biol Chem. 278(28): 26065-26070.

Rosas-Sandoval G, Ambrogelly A, Rinehart J, Wei D, Cruz-Vera LR, Graham DE, Stetter KO, Guarneros G, Soll D. (2002) Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast. Proc Natl Acad Sci U S A. Dec 24; 99(26): 16707-16712.

Cruz-Vera LR, Galindo JM, Guarneros G. (2002) Transcriptional analysis of the gene encoding peptidyl-tRNA hydrolase in Escherichia coli. Microbiology. 148(Pt 11): 3457-3466.

Dominguez-Martinez V, Guarneros-Pena G, Segura-Nieto M, Curiel-Quesada E. (2001) Construction of a multiframe vector to express coding sequences in Escherichia coli. Canadian Journal of Microbiology. 47:72-76.

Valadez JG, Hernandez-Sanchez J, Magos MA, Ontiveros C, Guarneros G. (2001) Increased bar minigene mRNA stability during cell growth inhibition. Mol Microbiol. 39(2): 361-369.

Cruz-Vera LR, Toledo I, Hernandez-Sanchez J, Guarneros G. (2000) Molecular basis for the temperature sensitivity of Escherichia coli pth(Ts). J Bacteriol. 182(6): 1523-1528.

Tenson T, Herrera JV, Kloss P, Guarneros G, Mankin AS. (1999) Inhibition of translation and cell growth by minigene expression. J Bacteriol. 181(5): 1617-1622.

 

 

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