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  • 17 / 12 / 2017
Cinvestav - Centro de Investigación y de Estudios Avanzados del I.P.N.

Dr. Luis Marat Alvarez Salas

Dr. Luis Marat Alvarez Salas

Grado:
Doctor en Ciencias 1990
Depto. de Genética y Biología Molecular
Cinvestav
México

Nivel SNI: 3

Tel: (55) 5747-3800 ext. 5387 y 5388
Fax: (55) 5747-3392
E-mail:
lalvarez@cinvestav.mx

Descriptores de la investigación:

Terapia genica. Tecnología antisentido. Software de Biología Molecular.

Líneas de Investigación:

Temas de Investigación:Temas de Investigación: Terapéutica de Ácidos Nucléicos. Desarrollo de software con aplicación a Biología Molecular. Terapia génica de cáncer cervical. Tecnología antisentido. Ribozimas y DNAzimas. Oligonucleótidos antisentido. ARN de interferencia y microARN (miRNA). Aptámeros y aptazimas Nanotecnología. Cáncer cervical y papilomavirus (VPH). 

Publicaciones recientes 

Palomino-Vizcaino G1, Valencia Reséndiz DG1, Benítez-Hess ML1, Martínez-Acuña N1, Tapia-Vieyra JV1, Bahena D2, Díaz-Sánchez M3, García-González OP3, Alvarez-Sandoval BA3, Alvarez-Salas LM4. (2017) Effect of HPV16 L1 virus-like particles on the aggregation of non-functionalized gold nanoparticles. Biosens Bioelectron. 4;100:176-183. doi: 10.1016/j.bios.2017.09.001.

 

Toscano-Garibay JD1, Benítez-Hess ML, Alvarez-Salas LM. (2017) Targeting of the HPV-16 E7 protein by RNA aptamers. Methods Mol Biol. 1249:221-39. doi: 10.1007/978-1-4939-2013-6-17.

 

Leija-Montoya AG1, Benítez-Hess ML, Toscano-Garibay JD, Alvarez-Salas LM. ( 2014) Characterization of an RNA aptamer against HPV-16 L1 virus-like particles. Nucleic Acid Ther. 24(5):344-355.

 

Benítez-Hess ML, Reyes-Gutiérrez P, Alvarez-Salas LM.  (2011) Inhibition of human papillomavirus expression using DNAzymes. Methods Mol Biol. 764:317-335.

 

López JA, Alvarez-Salas LM. (2011) Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation apoptosis, migration and invasion. Biochem Biophys Res Commun.409(3):513-519.

 

Toscano-Garibay JD, Benítez-Hess ML, Alvarez-Salas LM. (2011) Isolation and characterization of an RNA aptamer for the HPV-16 E7 oncoprotein. Arch Med Res. 42(2):88-96.

 

Aquino-Jarquin G1, Rojas-Hernández R, Alvarez-Salas LM (2010) Design and function of triplex hairpin ribozymes. Methods Mol Biol. 629:323-338.

 

Reyes-Gutiérrez P1, Alvarez-Salas LM. (2009) Cleavage of HPV-16 E6/E7 mRNA mediated by modified 10-23 deoxyribozymes. Oligonucleotides. 19(3):233-242.

 

Alvarez-Salas LM. (2008) Amolimogene bepiplasmid, a DNA-based therapeutic encoding the E6 and E7 epitopes from HPV, for cervical and anal dysplasia. Curr Opin Mol Ther. 10(6):622-628.

 

Alvarez-Salas LM. (2008) Nucleic acids as therapeutic agents. Curr Top Med Chem. 8(15):1379-1404.

 

Alvarez-Salas LM. (2008) A triplex ribozyme expression system based on a single hairpin ribozyme. Oligonucleotides. 18(3):213-224.

 

Alvarez-Salas LM, DiPaolo JA.  (2007) Molecular approaches to cervical cancer therapy. Curr Drug Discov Technol. 4(3):208-219.

 

Márquez-Gutiérrez MA, Benítez-Hess ML, DiPaolo JA, Alvarez-Salas LM. (2007) Effect of combined antisense oligodeoxynucleotides directed against the human papillomavirus type 16 on cervical carcinoma cells. Arch Med Res. 38(7):730-738. 

Guapillo MR1, Márquez MA, Benítez-Hess ML, Alvarez-Salas LM. (2006) A bacterial reporter system for the evaluation of antisense oligodeoxynucleotides directed against human papillomavirus type 16 (HPV-16). Arch Med Res. 37(5):584-592.

 

Alvarez-Salas LM1, Benitez-Hess ML, Dipaolo JA. (2005) YY-1 and c-Jun transcription factors participate in the repression of the human involucrin promoter. Int J Oncol. 26(1):259-266.

 

DiPaolo JA, Alvarez-Salas LM. (2004) Advances in the development of therapeutic nucleic acids against cervical cancer. Expert Opin Biol Ther.  4(8):1251-1264.

 

Acosta R, Montañez C, Fuentes-Mera L, Gonzalez E, Gómez P, Quintero-Mora L, Mornet D, Alvarez-Salas LM, Cisneros B. (2004) Dystrophin Dp71 is required for neurite outgrowth in PC12 cells. Exp Cell Res. 10;296(2):265-275.

 

Benítez-Hess ML, DiPaolo JA, Alvarez-Salas LM. (2004) Antisense activity detection by inhibition of fluorescence resonance energy transfer. Luminescence. 19(2):85-93.

 

Alvarez-Salas LM1, Benítez-Hess ML, DiPaolo JA. (2003) Advances in the development of ribozymes and antisense oligodeoxynucleotides as antiviral agents for human papillomaviruses. Antivir Ther. 2003 8(4):265-278.

 

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